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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN1
All Species:
11.52
Human Site:
Y315
Identified Species:
19.49
UniProt:
P49768
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49768
NP_000012.1
467
52668
Y315
R
V
S
K
N
S
K
Y
N
A
E
S
T
E
R
Chimpanzee
Pan troglodytes
XP_001149972
443
50485
G301
W
L
V
N
M
A
E
G
D
P
E
A
Q
R
R
Rhesus Macaque
Macaca mulatta
XP_001088524
384
43068
Q242
E
S
T
E
R
E
S
Q
D
T
V
A
E
N
D
Dog
Lupus familis
XP_547503
717
78133
E552
M
L
V
E
T
A
Q
E
R
N
E
P
I
F
P
Cat
Felis silvestris
Mouse
Mus musculus
P49769
467
52621
Y315
R
V
P
K
N
P
K
Y
N
T
Q
R
A
E
R
Rat
Rattus norvegicus
P97887
468
52771
S316
V
P
K
N
P
K
Y
S
T
Q
G
T
E
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
V313
V
E
N
S
A
E
E
V
D
H
Q
A
Q
E
E
Chicken
Gallus gallus
Q4JIM4
468
52812
Y316
K
A
S
K
N
S
T
Y
D
K
Q
A
P
A
N
Frog
Xenopus laevis
O12976
433
48282
S291
A
P
T
A
H
P
R
S
D
S
A
A
S
D
D
Zebra Danio
Brachydanio rerio
Q9W6T7
456
50963
V308
V
P
Q
Q
E
N
Q
V
V
A
M
A
P
T
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
S336
A
T
A
S
S
S
P
S
S
S
N
S
T
T
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
P302
A
S
C
S
S
E
T
P
K
R
P
K
V
K
R
Sea Urchin
Strong. purpuratus
XP_001178715
518
58077
E356
V
E
E
H
T
A
E
E
N
A
T
G
G
Q
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O64668
453
49290
S308
E
R
S
P
L
V
G
S
P
S
A
S
E
H
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.7
82.2
46.2
N.A.
92.7
92.5
N.A.
62.3
82.2
77.3
70.8
N.A.
47.6
N.A.
49
55.6
Protein Similarity:
100
90.7
82.2
52
N.A.
96.5
96.5
N.A.
73.6
89.7
83
79
N.A.
63.4
N.A.
64
68.1
P-Site Identity:
100
13.3
0
6.6
N.A.
60
0
N.A.
6.6
33.3
0
6.6
N.A.
20
N.A.
6.6
13.3
P-Site Similarity:
100
46.6
26.6
33.3
N.A.
66.6
6.6
N.A.
40
60
53.3
33.3
N.A.
46.6
N.A.
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
22
8
8
8
8
22
0
0
0
22
15
43
8
8
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
36
0
0
0
0
8
15
% D
% Glu:
15
15
8
15
8
22
22
15
0
0
22
0
22
22
22
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
8
8
0
0
8
8
8
0
0
% G
% His:
0
0
0
8
8
0
0
0
0
8
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
8
0
8
22
0
8
15
0
8
8
0
8
0
8
0
% K
% Leu:
0
15
0
0
8
0
0
0
0
0
0
0
0
0
0
% L
% Met:
8
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
8
15
22
8
0
0
22
8
8
0
0
8
8
% N
% Pro:
0
22
8
8
8
15
8
8
8
8
8
8
15
0
8
% P
% Gln:
0
0
8
8
0
0
15
8
0
8
22
0
15
8
0
% Q
% Arg:
15
8
0
0
8
0
8
0
8
8
0
8
0
15
29
% R
% Ser:
0
15
22
22
15
22
8
29
8
22
0
22
8
0
8
% S
% Thr:
0
8
15
0
15
0
15
0
8
15
8
8
15
15
8
% T
% Val:
29
15
15
0
0
8
0
15
8
0
8
0
8
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
22
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _